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In rats, this is accomplished through inbreeding. By having this kind of population, it is possible to conduct experiments on the roles of genes, or conduct experiments that exclude variations in genetics as a factor.

By contrast, outbred populations are used when identical genotypes are unnecessary or a population with genetic variation is required, and these rats are usually referred to as stocks rather than strains.

The Wistar rat is an outbred albino rat. This breed was developed at the Wistar Institute in for use in biological and medical research, and is notably the first rat developed to serve as a model organism at a time when laboratories primarily used the house mouse Mus musculus.

More than half of all laboratory rat strains are descended from the original colony established by physiologist Henry Donaldson, scientific administrator Milton J.

The Wistar rat is currently one of the most popular rats used for laboratory research. It is characterized by its wide head, long ears, and a tail length that is always less than its body length.

Wistar rats are more active than others like Sprague Dawley rats. The spontaneously hypertensive rat and the Lewis rat are other well-known stocks developed from Wistar rats.

The Long—Evans rat is an outbred rat developed by Drs. Long and Evans in by crossing several Wistar females with a wild gray male.

Long-Evans rats are white with a black hood, or occasionally white with a brown hood. They are utilized as a multipurpose model organism, frequently in behavioral and obesity research.

The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical and nutritional research.

The name was originally hyphenated, although the brand styling today Sprague Dawley, the trademark used by Envigo is not. The average litter size of the Sprague Dawley rat is These rats typically have a longer tail in proportion to their body length than Wistar rats.

However, since these rats are known to grow tumors at a high and very variable rate, the study was considered flawed in design and its findings unsubstantiated.

The biobreeding rat a. Like NOD mice , biobreeding rats are used as an animal model for Type 1 diabetes. The strain re-capitulates many of the features of human type 1 diabetes and has contributed greatly to the research of T1DM pathogenesis.

The Brattleboro rat is a strain that was developed by Henry A. It has a naturally occurring genetic mutation that makes specimens unable to produce the hormone vasopressin , which helps control kidney function.

The rats were being raised for laboratory use by Dr. Henry Schroeder and technician Tim Vinton, who noticed that the litter of 17 drank and urinated excessively.

Hairless laboratory rats provide researchers with valuable data regarding compromised immune systems and genetic kidney diseases.

It is estimated that there are over 25 genes that cause recessive hairlessness in laboratory rats. The Lewis rat was developed by Margaret Lewis from Wistar stock in the early s.

Characteristics include albino coloring, docile behavior, and low fertility. Second, Lewis rats are prone to develop a spontaneous transplantable lymphatic leukaemia.

Lastly, when in advanced age, they sometimes develop spontaneous glomerular sclerosis. Current research applications include transplantation research, induced arthritis and inflammation, experimental allergic encephalitis, and STZ-induced diabetes.

Although the genetic defect was not known for many years, it was identified in the year as a mutation in the gene MERTK.

This mutation results in defective retinal pigment epithelium phagocytosis of photoreceptor outer segments.

Its phenotype is similar to the widely researched reeler mouse. Shaking rat Kawasaki was first described in The Zucker rat was bred to be a genetic model for research on obesity and hypertension.

They are named after Lois M. Zucker and Theodore F. Zucker, pioneer researchers in the study of the genetics of obesity. Obese Zucker rats have high levels of lipids and cholesterol in their bloodstream, are resistant to insulin without being hyperglycemic , and gain weight from an increase in both the size and number of fat cells.

A knockout rat also spelled knock out or knock-out is a genetically engineered rat with a single gene turned off through a targeted mutation.

Knockout rats can mimic human diseases, and are important tools for studying gene function and for drug discovery and development. Knockout rat disease models for Parkinson's disease , Alzheimer's disease , hypertension , and diabetes , using zinc-finger nuclease technology, are being commercialized by SAGE Labs.

From Wikipedia, the free encyclopedia. Inbred strains of Rattus norvegicus used for scientific research. For other uses, see Lab rat disambiguation.

The albino laboratory rat with its red eyes and white fur is an iconic model organism for scientific research in a variety of fields.

Play media. Main article: Biobreeding rat. Main article: Brattleboro rat. See also: Hairless fancy rat. Main article: Knockout rat.

ILAR Journal. Academic Press. Bio Resource Newsletter. National Institute of Genetics. Retrieved 20 December Watson "Psychical development of the white rat", Ph.

Biographical Memoirs of the National Academy of Sciences. The oestrous cycle in the rat and its associated phenomena. University of California Press.

The Laboratory Rat. Archived from the original on 16 August Retrieved 15 September Retrieved 17 February Annual Editions: World History.

McGraw-Hill Higher Education. Sometimes, lilac colors may become confused with blue; but they are tinged with purple. Blue colored rats will not have any purple, silver, or brown tinge.

They are an all over, even color. I do not have a photo of a blue hooded to share, but this blue in the photo will demonstrate the proper coloring for a rat with a blue hood.

A chocolate colored rat is a nice, dark brown. A champagne hooded rat is much like an orange, red, or fawn hooded rat. While it can fall under the same general category with the quick glimpse, it is a VERY light color.

It is so light that a difference is barely seen between the champagne and the white. Rarely, you will see them with black eyes.

PHoto Courtesy of Laurel L. The Fawn, Champagne, or Beige hooded rat is more commonly called an orange hooded or red hooded by those who are not quite familiar with the rat colors.

There are also other shades, but these will be the three we mention here. These coats can range from a lighter beige that seems like a light orange, to a very fiery, deep color that reminds one of a redheaded human.

Meet Mouse, the Agouti Hooded Rat! Photo courtesy of Laurel L. The agouti color is a reddish cinnamon brown; it is multifaceted because the individual hairs are banded!

They are banded with varying shades of brown, red, cinnamon, black, and even gray.

Latin hood rats The spontaneously hypertensive rat and the Lewis rat are other well-known stocks developed from Wistar rats. Wistar rats are more active than others like Alicia von rittberg nude Dawley rats. American Rio hotties Association. Dumbo rats come in a wide variety of colors and coat types. More than half of all laboratory rat strains are descended from Cherie deville and darcie dolce original colony established by physiologist Henry Donaldson, scientific administrator Milton J. Most are derived from the albino Wistar rat, which is still widely used. Similar phrases in dictionary English Latin.

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